The drug furazolidone from which they drink. Furazolidone tablets for poisoning: composition, instructions for use and dosage

INSTRUCTIONS

for medical use.drug

Registration number LSR-004228/09-280509

Tradename: Furazolidone

International non-proprietary name:

Dosage form:

Composition:

ATX Code: G01AX06

Pharmaceutical code
Antimicrobial agent, a derivative of nitrofurans. Active against gram-positive and gram-negative microbes, Trichomonas spp., Ciardia lamblia. The most sensitive to furazolidone are Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp. Salmonella typhi, Salmonella paratyphi. Weakly affects pathogens of purulent and anaerobic infections. Microbial resistance develops slowly. Blocks monoamine oxidase.
Nitrofurans disrupt the processes of cellular respiration of microorganisms, suppress the tricarboxylic acid cycle (Krebs cycle), and also inhibit the biosynthesis of nucleic acids of microorganisms, resulting in the destruction of their shell or cytoplasmic membrane. As a result of the action of nitrofurans, microorganisms release less toxins, and therefore an improvement general condition the patient is possible even before a pronounced suppression of the growth of microflora. Unlike many other antimicrobial drugs, they not only do not inhibit, but even activate immune system organism (increase the complement titer and the ability of leukocytes to phagocytize microorganisms).

Pharmacokinetics
Well absorbed when administered orally. Against the backdrop of inflammation meninges in the cerebrospinal fluid, concentrations equal to those in plasma are created. It is rapidly and intensively metabolized mainly in the liver with the formation of a pharmacologically inactive metabolite (amino derivative). It is excreted mainly by the kidneys (65%), small amounts are found in the faeces, where therapeutic concentrations are reached against pathogens of intestinal infections.

Indications for use

Dysentery, paratyphoid, giardiasis, food poisoning.

Contraindications

Pregnancy, lactation. Increased individual sensitivity to the group of nitrofurans. End stage chronic kidney failure, deficiency of glucose-6-dehydrogenase, children under 3 years of age (for this dosage form).
Carefully

Chronic renal failure, glucose-6-phosphate dehydrogenase deficiency, liver disease and nervous system.

Dosage and administration

Inside, after eating. With dysentery, paratyphoid and food poisoning - 100-150 mg 4 times a day (but not more than 800 mg), for 5-10 days.
With giardiasis: adults - 100 mg 4 times a day, children - 10 mg / kg / day, distributing the daily dose into 3-4 doses. Higher single dose for adults - 200 mg; daily - 800 mg.

Side effect

Decreased appetite, up to anorexia; nausea, vomiting; allergic reactions (skin rash, hyperemia and itching of the skin, angioedema). With prolonged use - neuritis.

Overdose (intoxication) with the drug

Interaction with other drugs

special instructions

Composition

pharmachologic effect

The mechanism of the immunostimulatory action of the drug lies in its ability to increase the complement titer and the phagocytic activity of leukocytes. In addition, furazolidone reduces the production of toxins by microorganisms, resulting in an improvement in the overall clinical picture noted earlier than microbiological tests give a negative result.
The ability of furazolidone to inhibit monoamine oxidase was noted, which leads to lung development excitement in patients taking this drug. Furazolidone increases the body's sensitivity to ethyl alcohol, which can lead to the development of nausea and vomiting with the simultaneous use of alcohol and furazolidone.
The drug is effective in therapy infectious diseases caused by strains of microorganisms sensitive to the action of furazolidone, including:
Gram-positive and Gram-negative aerobic bacteria: Streptococcus spp., Staphylococcus spp., Shigella spp. (including Shigella dysenteria, Shigella boydii, Shigella sonnei), Salmonella typhi, Salmonella paratyphi, Esherichia coli, Proteus spp, Klebsiella spp, and bacteria of the genus Enterobacter .
The drug is also effective against protozoa, including Trichomonas spp., Lamblia spp.
In addition, the drug is effective against fungi of the genus Candida, however, before prescribing furazolidone for the treatment of candidiasis, sensitivity tests should be performed.
Microorganisms causing anaerobic and purulent infections are practically insensitive to furazolidone.

Drug resistance develops slowly.
After oral administration, the drug is rapidly absorbed in the gastrointestinal tract. In plasma, therapeutically significant concentrations of the drug are observed within 4-6 hours after oral administration. In patients suffering from meningitis, the concentrations of furazolidone in the cerebrospinal fluid correspond to those in the blood plasma. After absorption, the drug is rapidly metabolized in the body, mainly in the liver, with the formation of a pharmacologically inactive metabolite. Due to the rapid metabolism of the drug, there are no therapeutically significant concentrations of furazolidone in the blood and tissues (including the kidneys). It is excreted mainly by the kidneys, both unchanged and as a pharmacologically inactive metabolite. High therapeutic concentrations of the drug are observed in the intestinal lumen.
In patients with renal insufficiency, there is an accumulation of the drug in the body due to a decrease in the rate of its excretion by the kidneys.

Indications for use

Mode of application

Adults for the treatment of trichomonas colpitis are usually prescribed 0.1 g (2 tablets) of the drug 3-4 times a day orally in combination with drugs containing furazolidone, in the form of vaginal and rectal suppositories. Duration general course treatment 1-2 weeks, the duration of oral administration of the drug in complex therapy is 3 days.
The maximum single dose for adults is 0.2 g of the drug (4 tablets), daily - 0.8 g (16 tablets).
For children for the treatment of dysentery, paratyphoid and food poisoning, the dose is determined depending on age and body weight. The maximum duration of the course of treatment is 10 days.
Children for the treatment of giardiasis are usually prescribed a drug of 10 mg / kg of body weight per day. daily dose should be divided into 3-4 doses.
For treatment infected wounds and burns, the drug is prescribed in the form of irrigation or wet-drying dressings, having previously prepared a solution of furazolidone with a concentration of 1: 25,000.

Side effects

Contraindications

Pregnancy

drug interaction

Overdose

Release form

In contact with

Classmates

The description is up to date 22.02.2016

• Latin name: Furazolidone
• ATX code: G01AX06
• Active substance: Furazolidone
• Manufacturer: Veropharm (Belgorod, Russia), Marbiopharm (Russia), Irbit Chemical Pharmaceutical Plant (Russia), Borisovsky Plant medical preparations(Republic of Belarus)

In 1 tablet of furazolidone 0.05 g.

The composition also includes potato starch, calcium stearate, sucrose, polysorbate, lactose.

Plano-cylindrical tablets 0.05 g.

Granules for suspension preparation (for children).

pharmachologic effect

Antiprotozoal , antimicrobial .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Furazolidone - is an antimicrobial agent, a derivative nitrofuran . highly sensitive to it. salmonella , shigella , campylobacter , as well as the simplest ( lamblia , trichomonas ) and cholera vibrio . Depending on the concentration, it has a bactericidal or bacteriostatic effect.

The mechanism of action consists in the blockade of many enzyme systems of the microorganism. Nitrofurans disrupt cellular respiration, suppress Krebs cycle and block the biosynthesis nucleic acids . As a result, the shell of microorganisms or their cytoplasmic membrane is destroyed. Under the action of the drug, destroyed microbial cells release less toxins. Unlike other antimicrobial agents, they activate the immune system.

Works on strains resistant to some antibiotics. Not valid on anaerobes and Pseudomonas aeruginosa . Microbial resistance to the drug is rare.

What is Furazolidone used for? Since it is poorly absorbed in the gastrointestinal tract and at the same time creates high concentrations in the intestine, it is used for intestinal bacterial infections and protozoan etiology . Unlike Furadonin has low toxicity.

Pharmacokinetics

Well absorbed when taken orally. Distributed in tissues and fluids. In the liquor at meningitis the same concentrations are created as in plasma, therapeutic concentrations are also achieved in the intestinal lumen. Intensively metabolized in the liver to an inactive metabolite. Excreted by the kidneys (up to 65%), small amounts are determined in the feces,

Indications for the use of Furazolidone

• dysentery ;
• giardiasis ;
• cholera ;
• paratyphoid ;
• food poisoning ;
• trichomonas colpitis and urethritis ;
• pyelitis ;
• cystitis ;
• local treatment infected wounds and burns .

Contraindications

• hypersensitivity;
• pregnancy, breastfeeding;
• kidney failure (terminal stage);
• heavy liver failure ;
• age up to 3 years (tablets);
• age up to 1 month (suspension).

It is prescribed with caution in diseases of the nervous system and deficiency of glucose-6-phosphate dehydrogenase .

Side effects

• skin rash, itchy skin, angioedema ;
• loss of appetite;
• pulmonary edema , bronchospasm (with prolonged use);
• nausea, vomiting;
• hepatotoxic effect ;
• neuritis (with prolonged use).

Risk peripheral neuropathy increases with diabetes , hypovitaminosis B and FROM , anemia .

Furazolidone tablets, instructions for use (Method and dosage)

The drug is taken orally, after meals, because it can cause dyspeptic disorders . The tablets should be taken with a glass of water. With prolonged use for the purpose of prevention neuritis combined with admission B vitamins .

Instructions for use Furazolidone

Dose for adults at paratyphoid, dysentery and food poisoning- 0.1 g per day 4 times a day for 5-10 days. Single dose - 0.2 g, daily - 0.8 g.

At giardiasis- 0.1 g 4 times a day for up to 7 days, a week later repeat the same course.

At Trichomonas urethritis- 0.1 g 4 times for 3 days.

At Trichomonas colpitis the dosage and frequency of administration are the same and a powder containing furazolidone and milk sugar, in the rectum - suppositories, containing furazolidone 4-5 mg.

For treatment burns locally in the form of dressings with a solution of the drug (1: 25000).

Instructions for use for children

For children, the dose is calculated per kg of body weight. It is: one-time - 0.0025 g per kg, and daily 0.01 g per kg, distributed over 3-4 doses. The course of treatment is 5-7 days.

Application in veterinary medicine

The veterinary drug is a yellow powder, insoluble in water.

The drug is used for salmonellosis , coccidiosis , colibacillosis , enteritis , balantidiasis in animals and birds. You can also use a pharmaceutical preparation in tablets (in one tablet 50 mg).

The dosage for these diseases is the same for chickens, for turkeys and for broilers - the drug is added to the feed at the rate of 3 mg per head 2 times a day, the treatment is carried out for 8 days. If necessary, the course of treatment is repeated, but after a break of 10 days. Prophylactically, young animals up to 10 days of age are given daily 2 mg per head once a day.

An overdose is unacceptable, because the bird develops drowsiness, lethargy, and death may occur. How to give to chickens? Better with food. Another option is to dissolve in water and give as a drink. But you need to know that the drug dissolves poorly and loses its properties when exposed to sunlight.

Overdose

Manifested toxic hepatitis , polyneuritis and blood changes.

Treatment consists of discontinuing the drug, prescribing antihistamines and b vitamins , drinking plenty of water.

Interaction

Aminoglycosides and Tetracycline enhance its antimicrobial activity.

Antidepressants , Phenylephrine , Ephedrine , MAO inhibitors , Tyramine , Amphetamine in conjunction with furadonin cause a significant increase in blood pressure.

Means that alkalinize urine reduce the effect of the drug.

Inhibition of hematopoiesis is enhanced when used with Chloramphenicol and Ristomycin .

Incompatible with alcohol as this combination causes disulfiram-like reactions .

Terms of sale

Storage conditions

At a temperature not exceeding 25C.

Shelf life

Furazolidone for children

Instructions for children provide the following indications for use: amoebic dysentery , salmonellosis , giardiasis .

How to give Furazolidone to children?

For children, a convenient form of release is in the form of granules, from which a suspension is prepared by adding 100 ml of water. When properly prepared, 1 ml of the suspension will contain 0.0003 g of the drug. The suspension is used 4 times a day, measuring with a measuring cup and used up to 7 years of age. A single dose is: at 1-2 years, 4-5 ml, 3-4 years, 6-7 ml, 4-5 years, 7.5-8.5 ml.

From the age of 7, children can already take pills. The dosage of tablets for children is correspondingly less than for adults. At the age of 7-14 years, a single dose of 0.03-0.05 g is recommended, daily - 0.12 g -0.15 g.

Reviews of parents testify to its effectiveness in intestinal infections.

“They took bifiform and enterofuril - nothing helped. I had diarrhea for a week, until the doctor prescribed furazolidone + linex.

“Smecta didn’t help, enterofuril did the same, in the end furazolidone helped.”

Usually, no adverse reactions were noted for a 5-day period of administration.

Furazolidone during pregnancy

The drug belongs to category C. This means that in the study of the drug in animals, an adverse effect on the fetus was noted, but there are no data on the effect on the human fetus. According to the instructions, the drug is contraindicated during pregnancy. It can be prescribed only for vital necessity, taking into account the expected and the risk to the fetus.

Furazolidone for cystitis

How effective is this drug for cystitis ? Based on pharmacokinetics, its highest concentration is determined in the intestinal lumen, and hence it follows that the drug will be most effective in intestinal infections. From the group of nitrofurans in the treatment of urinary tract infections, it is better to use Furadonin however, it is more toxic.

If from cystitis Furazolidone can be used as monotherapy pyelitis and pyelonephritis it is given in combination with antibiotics . Derivatives of the nitrofuran series do not create therapeutic concentrations in the kidney parenchyma, so they are used only for cystitis.

Furazolidone tablets from cystitis in the usual dosages, which were mentioned above, are used in the uncomplicated course of the disease. At hemorrhagic or purulent cystitis more serious treatment is required.

Furazolidone for diarrhea

Is this drug always indicated? And is it possible to take it immediately with any disorder of the stool? There are clear indications shigellosis , amoebic dysentery , salmonellosis . The drugs of choice for the treatment of salmonellosis and shigellosis are fluoroquinolone drugs and furazolidone . Sometimes, even with an acute intestinal infection (AII) of mild and moderate form, especially in children, treatment begins with probiotics (Bifiform , Probifor , Enterol , Bifistim ) and enterosorbents ( Filtrum , Neosmectin , Enterosgel ). Only in severe forms or the absence of the effect of the previous treatment within 2-3 days are prescribed pills for diarrhea Furazolidone.

Only a doctor can prescribe how to take with diarrhea , and in the absence of positive dynamics, it is possible to switch to “reserve” antibiotics ( Imipenem , Azithromycin , Amikacin and etc.). Do not forget to take a course after treatment probiotics .

Furazolidone's analogs

There are no analogues for the active substance. Nirofuran derivatives have a similar effect. Nifuroxazide and Entprofuril , antibiotics Rifaximin , Imipenem , Azithromycin , Amikacin , Fluoroquinolone , Ciprofloxacin .

Reviews about Furazolidone

The question is often asked about this drug - is it an antibiotic or not? Is not antibiotic , a synthetic antibacterial agent , which differs from true antibiotics by the mechanism of action on microorganisms and the effect on the human body.

What is Furazolidone tablets for? Is it only when diarrhea prescribe this drug? Intestinal infections- this is the main indication for the use of the drug. In addition to Furazolidone, other intestinal antiseptics can be prescribed to correct the microflora ( Nifuroxazide , Rifaximin ) with subsequent use probiotics .

There are other indications for the use of Furazolidone, which the annotation does not indicate. For example, antihelicobacter therapy , including Furazolidone, is effective in the treatment of erosive and ulcerative diseases in adults. The same treatment regimen is used for children infected with chylicobacter pylori (HP) . It includes De-nol , Furazolidone, Amoxicillin , Ranitidine and after treatment, 100% eradication of HP is achieved.

Reviews often point to side effects drug - nausea and sometimes vomiting. When taking the drug without a doctor's prescription, carefully study all contraindications and follow the recommended doses.

Furazolidone price, where to buy

The drug is available in all pharmacies in Moscow and other cities of Russia, so you do not need a prescription in Latin to purchase the drug.

The price of Furazolidone tablets 50 mg No. 20 is 119-150 rubles.

Furazolidone is an antibacterial medicinal product belonging to the group of nitrofurans. Let's talk more about what it helps and how to take it.

"Furazolidone": indications for use

"Furazolidone" is prescribed for the treatment of infectious diseases of the genitourinary system, gastrointestinal tract or skin. In particular, it is effective for:

• paratyphoid;
• enterocolitis;
• typhus;
• giardiasis;
• diarrhea of ​​infectious etiology;
• bacillary dysentery.

You can also take "Furazolidone" with food poisoning, vaginitis, urethritis, pyelitis and cystitis. Often it is also used to treat patients who have infected burns and wounds.

How to take "Furazolidone": dosage

"Furazolidone" is taken orally. The tablet must be swallowed whole, it should not be chewed and crushed, it is permissible to drink a small amount of water. "Furazolidone" is taken after meals.

It is important when using this drug to observe the dosage:

• Paratyphoid, food poisoning, dysentery - 2-3 tablets 4 times a day. The course of treatment is from 5 to 10 days.
• Giardiasis, trichomonas urethritis - 2 tablets 4 times a day. The course of treatment is 3 days.
• Trichomonas colpitis - 2 tablets 3 times a day. The course of treatment is 1-2 weeks.

Dosage data are for adults. When using "Furazolidone" for the treatment of children, it is necessary to give the drug in an amount of 10 mg per 1 kg of body weight per day. The duration of its administration should not exceed 10 days.

If "Furazolidone" is used to treat infected burns and wounds, then it is necessary to make a solution, the concentration of which should be as follows: 1:25000. Compresses are made with this solution.

Contraindications and side effects

Furazolidone should not be used in the following cases:

• infants under the age of 1 month;
• lactose deficiency;
• diseases of the central nervous system;
• individual intolerance to the main components medicinal product;

It is important to consider that "Furazolidone" has a number of side effects:

• skin rash;
• angioedema;
• nausea and vomiting;
• anorexia;
• shortness of breath;
• coughing;
• hemolytic anemia (with prolonged use).

To reduce the likelihood of side effects, you should drink this drug along with B vitamins. If they still appear, you need to stop taking this medication and consult a specialist.

"Furazolidone" during pregnancy

The use of "Furazolidone" during pregnancy is not recommended, as it carries potential risks to the fetus. If the doctor nevertheless prescribed such a drug, then it should be taken with strict adherence to dosages. During the period of feeding, it should not be drunk, since "Furazolidone" can provoke hemolytic anemia at your baby.

"Furazolidone", what does this antibacterial medicine help with? The drug is not an antibiotic, belongs to the group of nitrofurans. "Furazolidone" helps against infectious intestinal pathologies, diarrhea, dysentery, cystitis, giardiasis.

Varieties and composition

In pharmacies, the medicine comes in the form of flat cylindrical tablets and a granular mixture to obtain a suspension. The last form of the drug "Furazolidone" is intended for children. Both tablets and suspensions contain 0.05 g of the active element furazolidone. Better absorption of the active substance is helped by: lactose, sucrose, starch, calcium stearate, polysorbate, which are part of the drug.

Pharmacology

The drug is isolated from nitrofurforol. The Furazolidone remedy, from which it helps with intestinal infections, is active against gram-negative anaerobic bacteria. The drug is less effective against fungi, gram-positive microbes and protozoa. The effect of the drug depends on the dosage. With its large volume, a bactericidal effect is observed, with a low dosage, bacteriostatic properties appear.

The active substance restores nitro groups to amino groups, which poison bacteria, violate the integrity of their cells, and stop biochemical processes. Because of this action, microbes stop growing and multiplying. A small immunostimulating effect of the drug has also been proven. It can increase the activity of leukocytes.

In addition, the tool increases sensitivity to ethylates. With the joint use of Furazolidone tablets and alcohol, a person experiences nausea and vomiting. Resistance to the drug in bacteria develops slowly, so it is effective over a long period.

The drug "Furazolidone": what helps

Indications for use include infections and inflammations skin, gastrointestinal and genitourinary systems. The medication is prescribed for:

• dysentery;
• cystitis;
• paratyphoid;
• pyelitis;
• giardiasis;
• urethritis or colpitis of trichomonas type;
• cholera;
• food poisoning and toxic infections;
• burns and infectious wounds.

Medicine "Furazolidone": instructions for use

The tablets are intended for internal use. They are washed down with plenty of water, do not chew. For the treatment of paratyphoid and food toxicosis, 150 mg of the drug is prescribed three times a day. Treatment continues for a week. With trichomonas infection and urethritis, it is necessary to drink 0.1 mg 4 times a day for three days. At the same time, the introduction of a powder containing lactose and furazolidone (5 g) into the vagina is indicated.

With giardiasis, tablets and suspension "Furazolidone" instructions for use require adults to take 0.1 g 4 times a day, children are given a suspension at the rate of 10 mg per kg of weight (for three times). For burns and festering wounds apply wet drying dressings with the drug "Furazolidone" or spray with a solution.

Contraindications

It is unacceptable to use the medication for:

• hypersensitivity;
• severe liver or kidney failure;
• pregnancy;
• lactation;
• children under 3 years (tablet form);
• up to 1 month (suspension).

Caution when using the medication must be observed in patients with ailments of the nervous system, as well as in case of insufficiency of glucose-phosphate dehydrogenase.

Side effects

The drug "Furazolidone" does not have toxicity, but its intake can provoke health problems. To side effects include:

• nausea or vomiting;
• edema;
• loss of appetite;
• skin rash;
• epigastric pain;
• hives.

To prevent such reactions, instructions for use and patient reviews recommend drinking Furazolidone with a large volume of liquid, using B vitamins and antiallergic drugs.

Analogues and price

You can replace the drug "Furazolidone" with nirofuran analogues, which include "Entprofuril" and "Nifuroxazide". The mechanism of action is similar to antibiotics: Ciprofloxacin, Azithromycin, Rifaximin. You can buy Furazolidone tablets, the price of which reaches 120 - 160 rubles, without a prescription.

Patient opinions

Many people ask: "Furazolidone" - is it an antibiotic or not? The medicine is not such, it has a completely different mechanism of action on the body and microbes. The drug belongs to synthetic antibacterial drugs.

Furazolidone - a drug (tablets), belongs to the group of antiseptics and antimicrobials for the treatment of gynecological diseases. Important Features medicinal product from the instructions for use:

• AT childhood: carefully
• With impaired liver function: with caution
• In case of impaired renal function: with caution

Package

Composition

In 1 tablet of furazolidone 0.05 g.

The composition also includes potato starch, calcium stearate, sucrose, polysorbate, lactose.

Release form

Plano-cylindrical tablets 0.05 g.

Granules for suspension preparation (for children).

pharmachologic effect

Antiprotozoal, antimicrobial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Furazolidone - is an antimicrobial agent, a derivative of nitrofuran. Salmonella, Shigella, Campylobacter, as well as protozoa (Labmlia, Trichomonas) and Vibrio cholerae are highly sensitive to it. Depending on the concentration, it has a bactericidal or bacteriostatic effect.

The mechanism of action consists in the blockade of many enzyme systems of the microorganism. Nitrofurans disrupt cellular respiration, inhibit the Krebs cycle and block the biosynthesis of nucleic acids. As a result, the shell of microorganisms or their cytoplasmic membrane is destroyed. Under the action of the drug, destroyed microbial cells release less toxins. Unlike other antimicrobial agents, they activate the immune system.

Works on strains resistant to some antibiotics. Does not affect anaerobes and Pseudomonas aeruginosa. Microbial resistance to the drug is rare.

What is Furazolidone used for? Since it is poorly absorbed in the gastrointestinal tract and high concentrations are created in the intestine, it is used for intestinal infections of bacterial and protozoal etiology. Unlike Furadonin, it has low toxicity.

Pharmacokinetics

Well absorbed when taken orally. Distributed in tissues and fluids. In cerebrospinal fluid with meningitis, the same concentrations are created as in plasma, and therapeutic concentrations are also achieved in the intestinal lumen. Intensively metabolized in the liver to an inactive metabolite. Excreted by the kidneys (up to 65%), small amounts are determined in the feces,

Indications for the use of Furazolidone

• dysentery;
• giardiasis;
• cholera;
• paratyphoid;
• food poisoning;
• trichomonas colpitis and urethritis;
• pyelitis;
• cystitis;
• topical treatment of infected wounds and burns.

Contraindications

• hypersensitivity;
• pregnancy, breastfeeding;
• renal failure (terminal stage);
• severe liver failure;
• age up to 3 years (tablets);
• age up to 1 month (suspension).

It is prescribed with caution in diseases of the nervous system and deficiency of glucose-6-phosphate dehydrogenase.

Side effects

• skin rash, skin itching, Quincke's edema;
• loss of appetite;
• pulmonary edema, bronchospasm (with prolonged use);
• nausea, vomiting;
• hepatotoxic action;
• neuritis (with prolonged use).

The risk of peripheral neuropathy increases with diabetes mellitus, hypovitaminosis B and C, anemia.

Furazolidone tablets, instructions for use (Method and dosage)

The drug is taken orally, after meals, as it can cause dyspeptic disorders. The tablets should be taken with a glass of water. With prolonged use, in order to prevent neuritis, they are combined with the intake of B vitamins.

Instructions for use Furazolidone

The dose for adults with paratyphoid fever, dysentery and food poisoning is 0.1 g per day 4 times a day for 5-10 days. Single dose - 0.2 g, daily - 0.8 g.

With giardiasis - 0.1 g 4 times a day for up to 7 days, a week later the same course is repeated.

With trichomonas urethritis - 0.1 g 4 times for 3 days.

With trichomonas colpitis, the dosage and frequency of administration are the same and a powder containing furazolidone and milk sugar is simultaneously injected into the vagina, suppositories containing 4-5 mg of furazolidone are injected into the rectum.

For the treatment of burns locally in the form of dressings with a solution of the drug (1:25000).

Instructions for use for children

For children, the dose is calculated per kg of body weight. It is: one-time - 0.0025 g per kg, and daily 0.01 g per kg, distributed over 3-4 doses. The course of treatment is 5-7 days.

Application in veterinary medicine

The veterinary drug is a yellow powder, insoluble in water.

The drug is used for salmonellosis, coccidiosis, colibacillosis, enteritis, balantidiasis in animals and birds. You can also use a pharmaceutical preparation in tablets (in one tablet 50 mg).

The dosage for these diseases is the same for chickens, for turkeys and for broilers - the drug is added to the feed at the rate of 3 mg per head 2 times a day, the treatment is carried out for 8 days. If necessary, the course of treatment is repeated, but after a break of 10 days. Prophylactically, young animals up to 10 days of age are given daily 2 mg per head once a day.

An overdose is unacceptable, because the bird develops drowsiness, lethargy, and death may occur. How to give to chickens? Better with food. Another option is to dissolve in water and give as a drink. But you need to know that the drug dissolves poorly and loses its properties when exposed to sunlight.

Overdose

Manifested by toxic hepatitis, polyneuritis and changes in the blood.

Treatment consists in the abolition of the drug, the appointment of antihistamines and B vitamins, drinking plenty of water.

Interaction

Aminoglycosides and tetracycline enhance its antimicrobial action.

Antidepressants, Phenylephrine, Ephedrine, MAO inhibitors, Tyramine, Amphetamine in combination with furadonin cause a significant increase in blood pressure.

Means that alkalinize urine reduce the effect of the drug.

Inhibition of hematopoiesis is enhanced when used with Chloramphenicol and Ristomycin.

Incompatible with alcohol, since this combination causes disulfiram-like reactions.

Terms of sale

Without recipe.

Storage conditions

At a temperature not exceeding 25C.

Shelf life

Furazolidone for children

The instruction for children provides for the following indications for use: amoebic dysentery, salmonellosis, giardiasis.

How to give Furazolidone to children?

For children, a convenient form of release is in the form of granules, from which a suspension is prepared by adding 100 ml of water. When properly prepared, 1 ml of the suspension will contain 0.0003 g of the drug. The suspension is used 4 times a day, measuring with a measuring cup and used up to 7 years of age. A single dose is: at 1-2 years, 4-5 ml, 3-4 years, 6-7 ml, 4-5 years, 7.5-8.5 ml.

From the age of 7, children can already take pills. The dosage of tablets for children is correspondingly less than for adults. At the age of 7-14 years, a single dose of 0.03-0.05 g is recommended, daily - 0.12 g -0.15 g.

Reviews of parents testify to its effectiveness in intestinal infections.

“They took bifiform and enterofuril - nothing helped. I had diarrhea for a week, until the doctor prescribed furazolidone + linex.

“Smecta didn’t help, enterofuril did the same, in the end furazolidone helped.”

Usually, no adverse reactions were noted for a 5-day period of administration.

Furazolidone during pregnancy

The drug belongs to category C. This means that in the study of the drug in animals, an adverse effect on the fetus was noted, but there are no data on the effect on the human fetus. According to the instructions, the drug is contraindicated during pregnancy. It can be prescribed only for vital necessity, taking into account the expected and the risk to the fetus.

Furazolidone for cystitis

How effective is this drug for cystitis? Based on pharmacokinetics, its highest concentration is determined in the intestinal lumen, and hence it follows that the drug will be most effective in intestinal infections. From the group of nitrofurans, it is better to use Furadonin in the treatment of urinary tract infections, but it is more toxic.

If Furazolidone can be used as monotherapy for cystitis, then for pyelitis and pyelonephritis it is prescribed in combination with antibiotics. Derivatives of the nitrofuran series do not create therapeutic concentrations in the kidney parenchyma, so they are used only for cystitis.

Furazolidone tablets from cystitis in the usual dosages, which were mentioned above, are used in the uncomplicated course of the disease. With hemorrhagic or purulent cystitis, more serious treatment is required.

Furazolidone for diarrhea

Is this drug always indicated? And is it possible to take it immediately with any disorder of the stool? There are clear indications - shigellosis, amoebic dysentery, salmonellosis. The drugs of choice for the treatment of salmonellosis and shigellosis are fluoroquinolone drugs and furazolidone. Sometimes even with an acute intestinal infection (AII) of mild and moderate form, especially in children, treatment begins with probiotics (Bifiform, Probifor, Enterol, Bifistim) and enterosorbents (Filtrum, Neosmectin, Enterosgel). Only in severe forms or the absence of the effect of the previous treatment within 2-3 days are prescribed pills for diarrhea Furazolidone.

Only a doctor can prescribe how to take it for diarrhea, and in the absence of positive dynamics, it is possible to switch to “reserve” antibiotics (Imipenem, Azithromycin, Amikacin, etc.). Do not forget to take a course of probiotics after treatment.

Furazolidone's analogs

There are no analogues for the active substance. Nifuroxazide and Entprofuril nirofuran derivatives, antibiotics Rifaximin, Imipenem, Azithromycin, Amikacin, Fluoroquinolone, Ciprofloxacin have a similar effect.

Reviews about Furazolidone

The question is often asked about this drug - is it an antibiotic or not? This is not an antibiotic, but a synthetic antibacterial agent, which differs from true antibiotics by the mechanism of action on microorganisms and the effect on the human body.

What is Furazolidone tablets for? Is this drug prescribed only for diarrhea? Intestinal infections are the main indication for the use of the drug. In addition to Furazolidone, other intestinal antiseptics (Nifuroxazid, Rifaximin) can be prescribed for the correction of microflora, followed by the use of probiotics.

There are other indications for the use of Furazolidone, which the annotation does not indicate. For example, anti-Helicobacter therapy, including Furazolidone, is effective in the treatment of erosive and ulcerative diseases in adults. The same treatment regimen is used for children infected with Helicobacter pylori (HP). It includes De-nol, Furazolidone, Amoxicillin, Ranitidine and after treatment 100% HP eradication is achieved.

The reviews often indicate the side effects of the drug - nausea and sometimes vomiting. When taking the drug without a doctor's prescription, carefully study all contraindications and follow the recommended doses.

Furazolidone price, where to buy

The drug is available in all pharmacies in Moscow and other cities of Russia, so you do not need a prescription in Latin to purchase the drug.

The price of Furazolidone tablets 50 mg No. 20 is 119-150 rubles.

Europharm* 4% discount with promo code medside11

The drug from my drink, Furazolidone "// Explanatory video.

Furazolidone | instructions for use

Furazolidone tablets description and instructions - CLOSE-UP *

★ Furazolidone for giardiasis. Also effective against a number of bacteria and dysentery

Furazolidone refers to antiseptic and antimicrobial agents and monoamine oxidase inhibitors. Main active substance- furazolidone, a derivative of nitrofurans. Features of admission and recommended treatment regimens are described in the information provided.

The composition of the medicinal product

The main active ingredient is furazolidone. Additional components: potato starch, lactose, calcium stearate. The shelf life of the drug is 3 years after release.

Pharmacological properties

This drug is a synthetic derivative of nitrofurfurol. It has antimicrobial activity against gram-negative aerobic bacteria, some types of gram-positive aerobic microorganisms, protozoa and fungi.

The action depends on the dosage of the drug. So, when using small doses of furazolidone, a bacteriostatic effect is pronounced. With an increase in dosage, an increased bactericidal activity is observed. The antimicrobial effect lies in the ability of furazolidone to recover to the amino group. As a result of this process, substances are formed that have a toxic effect on bacterial cells. They destroy the outer shell, block the biochemical processes of pathogenic microorganisms at the cellular level. The use of furazolidone provokes the blockade of NADH and disturbances in the cellular respiration of microorganisms. This inhibits growth and reproduction and leads to the death of the above groups of bacteria.

Furazolidone has a slight immunostimulating effect, increasing the phagocytic activity of leukocytes. In addition, when taking the drug, the production of toxins by microorganisms is reduced, which improves the clinical picture.

The drug belongs to the group of monoamine oxidase inhibitors, therefore it has a slight excitation of the nervous system and increases sensitivity to ethyl alcohol. This increases the chance of side effects when simultaneous reception alcohol during treatment.

Insensitivity to furazolidone is manifested by pathogens of anaerobic and purulent infections. Addiction to the drug develops very slowly. After taking furazolidone, the active ingredients are rapidly absorbed in the gastrointestinal tract. In blood plasma, the maximum values ​​are observed after 4-6 hours of administration. Metabolization occurs predominantly in the liver, and the process occurs at such a rate that it does not allow accumulation in tissues and does not significantly affect activity. internal organs in particular the kidneys. Excreted by the kidneys (about 65%), reaches significant values ​​in the bile duct and intestinal lumen, which allows the drug to be used to treat local infections.

Release form

Forms of release of the drug

Furazolidone is available in the form of tablets. The package contains two blisters of 10 tablets containing active substance 50 mg. The tablets are suitable for oral administration, preparation disinfectant solution. In veterinary practice, furazolidone powder is used for local application.

Indications for use

The drug is effective in the treatment of infectious diseases caused by strains of microorganisms sensitive to the action of furazolidone.

These include:

1. Aerobic bacteria (gram-positive and gram-negative): Streptococcus spp., Staphylococcus spp., Shigella spp., Shigella dysenteria, Shigella boydii, Shigella sonnei, Salmonella typhi, Salmonella paratyphi, Esherichia coli, Proteus spp, Klebsiella spp. and bacteria of the genus Enterobacter;
2. The simplest microorganisms. Trichomonas spp., Lamblia spp.;
3. Fungal infections caused by the causative agent of the genus Candida.

Before prescribing furazolidone for the treatment of candidiasis, it is better to conduct sensitivity tests.

The pharmacological action of the drug allows it to be used in the treatment of the following diseases:

• Infections of the gastrointestinal tract;
• Trichomonas infection;
• Bacillary dysentery;
• Giardiasis of various localization;
• In the treatment of skin diseases;
• In the treatment of infected wounds and burns.

Possible contraindications

The drug has a complex effect on the body, but, due to its rapid elimination, it does not have many contraindications. When prescribing a course of treatment, it is worth consulting with a doctor, informing about already existing diseases and states.

Furazolidone should not be used:

• Children under one year of age;
• Individual sensitivity to the components of the drug;
• With thermal (last) stage of renal failure;
• Pathologies of the central nervous system;
• Enzyme deficiency;
• During lactation;
• With hepatic pathologies.

In acute renal failure, the accumulation of the drug occurs due to the low rate of metabolism and excretion, therefore, the question of the advisability of treating such patients with this drug is decided by the attending physician.

Instructions for use

Furazolidone is taken orally, strictly after meals. Tablets are not chewed with water. For children, it is better to grind the prescribed amount of medicine and mix it with a small portion of water. The drug does not have a pronounced taste, it is able to color urine yellow.

The following schemes are used in the treatment:

• For the treatment of infections of the gastrointestinal tract, the drug is prescribed two tablets three times a day. The course of treatment is 5 - 10 days, depending on the severity of the condition. The maximum dosage for adults is 800 mg (16 tablets).
• In pediatrics, the dosage is calculated depending on the age and body weight of the patient. The daily dose should not exceed 10 mg / kg of body weight, while it is necessary to divide the medicine into three to four doses.
• In the treatment of infections of the genitourinary system, the same doses of the drug are used. The course of admission is three days.
• For the treatment of vaginal infection, it is more expedient to use furazolidone preparations in the form of suppositories.
• Topical use in the treatment of infected wounds and burns is applied in the form of irrigation or the use of wet-drying dressings. Solution for topical application is prepared at the rate of 1:25000. Such solutions are also often used in surgical practice to prevent infection of postoperative sutures or to treat the surface of the skin before manipulation.

Furazolidone during pregnancy

Furazolidone during pregnancy

Patients bearing a child, use the drug only after medical consultation. The specialist will be able to weigh and evaluate possible harm for the child and benefit for the mother. Usually drugs of other groups with a similar effect are used.

For the period of treatment with Furazolidone should be discontinued breast-feeding. The active components of the drug are able to penetrate into breast milk, so they can harm the health of the child.

drug interaction

Furazolidone is able to reduce the reaction rate, therefore, during the period of treatment, it is not recommended to perform work that requires maximum concentration. These include the management of transport, cargo and lifting mechanisms.

Be sure to exclude the intake of alcohol, because the combination of the drug with ethyl alcohol increases the toxic load on the liver and kidneys. There may be individual reactions: nausea, vomiting, indigestion. In addition, cases of tachycardia and impaired brain activity are known. That is why furazolidone and alcohol are incompatible.

An extremely negative effect is observed with the simultaneous use of vasoconstrictor drugs, or food products with a similar effect. These include chocolate, coffee and strong tea. Also avoid foods containing lactose. This may lead to the development adverse events, since the product contains a certain amount of lactose in the composition.

Side effects

In case of violations of the regimen of administration and recommended dosages, negative reactions of the body are possible. To reduce the likelihood of such manifestations, tablets should be taken with plenty of plain water, and for the duration of treatment, additional drugs containing B vitamins should be taken. Modern hepatoprotectors or drugs with a similar effect can be used to protect the liver.

Side effects of the drug include:

• Nausea, vomiting;
• Pain in the epigastric region;
• Skin rashes, urticaria;
• Quincke's edema;
• headache, dizziness;
• Increased drowsiness and fatigue;
• Feverish conditions;
• hypoglycemia;
• Decreased appetite.

In general, this group of drugs is classified as low-toxic. Subject to the prescribed duration and dosage during treatment, the appearance of negative symptoms is unlikely. If, however, negative reactions after Furazolidone occur, you should stop taking it and inform your doctor about it.

The cost of the drug

Furazolidone is distinguished by a very affordable price. On average, the cost of a package of 20 tablets ranges from 95 to 115 rubles, depending on the country of manufacture.

Analogues and comparison

Usually the drug is well tolerated and does not require replacement. In addition, furazolidone is distinguished by affordable cost and a wide range of applications, but for some categories of patients, the use of similar agents would be the best option.

Drugs with a similar effect:

Direct derivatives of furazolidone are Furadonin, Furagin, Furmag and Furatsilin. In these medicines, the active ingredient is presented in different concentrations, so before using it is necessary to read the instructions or consult with your doctor.

Furazolidone is a time-tested antiseptic, often used in the treatment of infections of various origins. It has an antimicrobial effect on many known strains of bacteria and other microorganisms, and is also used to eliminate candidiasis. It is better to coordinate the treatment regimen and dosage with the doctor, because the drug also has contraindications. Features of reception at various diseases covered in our information.